FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs., 3 Treatments

4.4 4.4 out of 5 stars | 46,620 ratings

Price: 39.98

Last update: 12-14-2024


About this item

Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus

Product information


Top reviews from the United States

Guitarasaurus
5.0 out of 5 stars Kills fleas
Reviewed in the United States on May 9, 2024
If you've had a pet with fleas you know it quickly becomes a nightmare. After finding your socks and ankles have fleas and bites you snap. You take matters in your own hands. But they somehow dont die. No. Tiger pits, dropping anvils, 12 gauge....they always survive, like they're thumbing their nose at you.

My neighbor came by after hearing a couple of frags going off in my home. The little zombies still hadn't died and I was filled with rage, frustration, and flea bites. He recommended Frontline. This stuff works. It makes the little vampires sterile. At first there's no break. But after 3 days I did notice a small difference. 10 days in I barely saw a flea. 14 days until several years later (now) fleas have been non existent. It does kill ticks, and it kills fleas eggs, or maybe flea hatchlings. Don't remember. What I do remember is this stuff works great. And my dog is happier
Kimberly Zittlow
5.0 out of 5 stars Frontline Plus for Large Dogs
Reviewed in the United States on November 22, 2024
Frontline Plus is my go-to flea and tick solution for my large dog! I have a big Blue Heeler who loves spending time outdoors, rolling in the grass, and exploring wooded trails. This product has been a total game changer for keeping him pest-free and happy.

Applying it is super simple. The applicator is well-designed to make sure the liquid goes directly onto the skin, and it dries quickly, so there’s no mess or greasy residue. I love that I don’t have to worry about fleas or ticks for a full month—it’s long-lasting and incredibly effective.

Since using Frontline Plus, I’ve noticed a huge improvement. No more scratching or irritability, and I haven’t spotted a single flea or tick on him, even after long hikes. It gives me peace of mind knowing he’s protected, especially since ticks can carry dangerous diseases.

Another big plus is that this product works without causing any side effects. My Heeler has sensitive skin, and I’ve never had issues with irritation or reactions. It’s clear that Frontline takes pet safety seriously.

If you have a large, active dog like mine, this is a must-have for keeping pests at bay. It’s worth every penny for the protection and comfort it provides. Highly recommend!
Customer image
Kimberly Zittlow
5.0 out of 5 stars Frontline Plus for Large Dogs
Reviewed in the United States on November 22, 2024
Frontline Plus is my go-to flea and tick solution for my large dog! I have a big Blue Heeler who loves spending time outdoors, rolling in the grass, and exploring wooded trails. This product has been a total game changer for keeping him pest-free and happy.

Applying it is super simple. The applicator is well-designed to make sure the liquid goes directly onto the skin, and it dries quickly, so there’s no mess or greasy residue. I love that I don’t have to worry about fleas or ticks for a full month—it’s long-lasting and incredibly effective.

Since using Frontline Plus, I’ve noticed a huge improvement. No more scratching or irritability, and I haven’t spotted a single flea or tick on him, even after long hikes. It gives me peace of mind knowing he’s protected, especially since ticks can carry dangerous diseases.

Another big plus is that this product works without causing any side effects. My Heeler has sensitive skin, and I’ve never had issues with irritation or reactions. It’s clear that Frontline takes pet safety seriously.

If you have a large, active dog like mine, this is a must-have for keeping pests at bay. It’s worth every penny for the protection and comfort it provides. Highly recommend!
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Arrowhead
5.0 out of 5 stars Best Value
Reviewed in the United States on November 16, 2024
People say Frontline Plus is 'old school' , but if 'old school' works, why stop using it? It does a great job of killing fleas and ticks on my 2 pets. I will continue to purchase Frontline products. Also, they're safe to use, unlike some other new, more expensive products that your vet will try and sell you.
Peter Suslock
4.0 out of 5 stars Your Safest Bet For A Product You Wish You Didn't Need.
Reviewed in the United States on August 18, 2012
Allow me to caveat this review by saying out of 700 plus reviews this is the most difficult to write as I despise having to use pesticides on our dogs. That said, we live in Tick and Flea central, surrounded by deep woods and our bulldogs are in every sense of the word family and we do whatever we must to protect them. That said if you're reading these reviews your dog or dogs are your heart too and using these products is a difficult choice to make, but it's one we have to make.

On that note, it's my hope the following information has some value for you.

Frontline was first put into clinical trials in 1985 shortly after the discovery of it's active ingredient Fipronil. To it's credit Frontline has maintained the safest albeit not the most effective treatment for fleas and ticks. However, the more effective products pose a significantly greater risk to your dog.
It's a slippery slope, but in evaluating what's best for your dog by providing the highest level protection with the lowest risk Frontline and FrontLine Plus are in my opinion your best bet.

Most tick and flea products contain Permethrin which may also be listed as Lyclear or Nix as the active ingredient. Permethrin is a lethal neurotoxin that flows through the dogs circulatory system and flushes into every major organ - including the brain where it can do dire damage. Thousands of dogs die every year from Permethrin. Although the FDA has mandated a minimal use not to exceed 750PPM companies continue to ignore the guidline because it's cheap and effective, and sadly it's our dogs that pay the price.

What makes Permethrin so dangerous is that it can't distinguish between insects and mammals which of course includes human beings. It's been known to be lethal to cats since the 1970's. In fact it's so deadly to cats that even a slight transfer from dog to cat can result in seizures, brain damage and death. Permethrin is volatile as well - meaning it's airborne properties pose a threat to all who breath it in - humans included.

Frontline on the other hand uses Fipronil. Fipronil is an insecticide.

Like any chemical of this nature it can be lethal at too high of a dose. However studies including those from the Department of Environmental Conservation have determined time and time again that as long as the amount of Fipronil is at the correct dose for the weight and size of your dog toxicity is far easier to avoid and the product much safer for your dog. Unlike Premethrin, Fipronil is absorbed into the hair follicles and oil glands only. It is not absorbed into the dogs system nor is it volatile so you and your beloved pets and children can breath easy. The second active ingredient in FrontLine Plus is Methoprene which is a long existing and time proven IGR (insect growth regulator) it's distributed exactly like Fipronil but only acts on flea and tick eggs and Larvae - this is important because it kills these vermin at the start of a new life cycle. What is more, the diseases that ticks carry now are infinitely more serious than the dreaded Lime disease - which for decades was the only concern.

Competitors to Frontline (and some Vets selling other products) claim that fleas and ticks have become resistant to Frontline - However these pests have become resistant to some degree to all pesticides and no independent research exists to confirm this claim. I can assure you I've researched this in the greatest depth.

The bottom line is this - all of these products pose a risk.

The wise choice is to minimize that risk in your effort to protect your best friend from the diseases these vermin carry. Again, these diseases can be infinitely more lethal than the ingredients of the protection. To that end your safest and most effective choice is Frontline or Frontline Plus.

In the event your pet has a bad reaction to Frontline products these are the symptoms you would see:

* Restlessness

* Itching

* Vomiting

* Difficulty Breathing

* Lethargy

Should these symptoms occur, of course take your pet to your Veterinarian or emergency clinic immediately. It should be a comfort to know that unlike the toxic ingredients in most other flea and tick control products severe reactions to both Fipronil and Methoprene are rare.
Onehappymomma16
5.0 out of 5 stars Works!
Reviewed in the United States on November 27, 2024
This works great for my 60lb pup! I’m not crazy about the greasy looking spot it leaves on her beautiful long fur after applying but she is tick and flea free! Thankfully she has not experienced any side effects from this brand!
MattyD14
5.0 out of 5 stars 45 Pit Mix is flea free
Reviewed in the United States on September 23, 2024
Frontline Plus for Dogs has been my go-to flea and tick treatment for my 45-pound pit mix, and it’s worked like a charm. I’ve been using it consistently, and she’s stayed flea-free, even during the warmer months when pests are usually a problem. The six-dose pack is a good value and lasts a while, giving me peace of mind that she’s covered. Application is easy, and she hasn’t had any reactions to it, which is a relief. Overall, it’s been reliable, and I don’t see myself switching anytime soon.

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